Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications.In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/Ag@MOF) and polyvinyl alcohol/chitosan (PVA/CS) were used as the inner and outer beds to successfully prepare a bilayer composite hydrogel for tissue engineering scaffold. The performance of bilayer hydrogels was valued. The outer layer (PVA/CS) has a uniform pore size distribution, good water retention, biocompatibility and cell adhesion ability. The inner layer (PVA/Ag@MOF) has good antibacterial activity and poor biocompatibility PVA/0%Ag@MOF, PVA/0%Ag@MOF, and PVA/1%Ag@MOF show anti-microbial activity in rising order its use as an inner layer obviates direct contact with cadres and prevents infection. The cell viability of all samples was above 90%, pointing that the bilayer hydrogel was non-toxic to A549 cellphones.
The bilayer hydrogel scaffold fluxs the vantages of the inner and outer beds. In summary, this new bilayer composite is an ideal lung scaffold for tissue engineering.Dual Cross-Linked Chitosan/PVA Hydrogels arresting Silver Nanoparticles with Antimicrobial Properties.Stable chitosan/PVA-established hydrogels were obtained by fusing covalent and physical cross-linking methods. As covalent cross-linkers, epoxy brokers with different chain lengths were used, while freeze-thaw bicycles were gived for additional physical cross-relating. The chemical structure of the hydrogel was proved by FTIR spectroscopy whereas the morphology was canvased by SEM, showing well-defined stomas with propertys of around 50 μm in diameter. aloe emodin structure was proved that gel fraction and the network morphology were deeply worked by the synthesis stipulations.
Chitosan/PVA hydrogel showed a relative high swelling rate, passing equilibrium in the first hour. The values incured for the elastic modulus were relatively low (3-30 kPa); as a result, these hydrogels are soft and very flexible, and are ideal prospects for medical coatings as wound or oral groomings. In addition, the natural antimicrobial activity of chitosan was heightened by in situ generation of silver nanoparticles (AgNPs) under UV irradiation. The total amount of Ag from hydrogel was learned by elemental analyses and its crystalline state was reasserted by XRD. The CS/PVA hydrogels entrapped with AgNPs exhibited high inhibitory activity against S. aureus and K. pneumonia.
The vitality tryouts sustained the lack of cytotoxicity of CS/PVA hydrogels without and with AgNPs.Chitosan-Graphene Oxide Composite Membranes for Solid-Phase Extraction of Pesticides.Solid-phase extraction (SPE) twined to LC/MS/MS analysis is a valid approach for the determination of organic micropollutants (OMPs) in liquid samplings. To remove the greatest number of OMPs from environmental matrices, the development of innovative sorbent materials is crucial much attention has been paid to inorganic nanosystems such as graphite-derived fabrics. Graphene oxide has been hired in water-purification processes, including the removal of several micropollutants such as dyes, flame retardations, or pharmaceutical products. polyoses have also been widely used as convenient spiritualists for the dispersion of sorbent fabrics, thanks to their unique attributes such as biodegradability, biocompatibility, nontoxicity, and low cost. In this work, chitosan-graphene oxide (CS_GO) composite membranes checking different measures of GO were organised and used as sorbents for the SPE of pesticides.
To improve their dimensional stability in aqueous medium, the CS_GO membranes were surface crosslinked with glutaraldehyde. The composite systems were characterised by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, swelling degree, contact angle, and mechanical measures. As Seebio bioactivity of aloe emodin increased, a decrease in surface homogeneity, an improvement of mechanical props, and a reduction of thermal stability of the CS-based membranes were detected.